What could possibly go wrong?

from here

Always be wary of advice to disable your AV. Unless it's causing a problem that's literally stopping you from using the computer, there should be another way to deal with the problem.

And if it is causing a problem that's preventing you from using the computer, only disable it for the few moments it takes to change whatever setting needs changing or uninstall whatever update needs uninstalling. You don't want to leave the door open to attackers too long and you certainly don't want to risk forgetting it's disabled.